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VU0420373

CAT: 0804-HY-115658-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115658-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].
CAS Number
38376-29-3
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/vu0420373.html
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=CC=C1C2=NNC(C3=CC=CC=C3F)=C2
Molecular Formula
C15H11FN2O
Molecular Weight
254.26
Precautions
H302
References & Citations
[1]Brendan F Dutter, et al. Decoupling Activation of Heme Biosynthesis From Anaerobic Toxicity in a Molecule Active in Staphylococcus Aureus. ACS Chem Biol. 2016 May 20;11 (5) :1354-61.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5803112VU0420373

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