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YX968

CAT: 0804-HY-164233-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164233-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YX968 is a potent and selective HDAC3/8 PROTAC dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1]. (Pink: Target protein ligand ; Black: linker (HY-W007700) ; Blue: E3 ligase ligand (HY-112078) )
CAS Number
2742732-92-7
UNSPSC
12352005
Target
Apoptosis; HDAC; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yx968.html
Purity
98.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCNNC(C(C=C1)=CC=C1N(CC2)CCN2CCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)=O
Molecular Formula
C45H66N8O5S
Molecular Weight
831.12
References & Citations
[1]Xiao Y, et al. HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation. Cell Chem Biol. 2023 Nov 16;30 (11) :1421-1435.e12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC3; HDAC8

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