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Cambinol

CAT: 0804-HY-100732-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-100732-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [1][2].
CAS Number
14513-15-6
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Phospholipase; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cambinol.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S
Molecular Formula
C21H16N2O2S
Molecular Weight
360.43
Precautions
H302
References & Citations
[1]Heltweg B, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66 (8) :4368-77.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2

Alternative Products

CatalogName
MBS3607300-01Cambinol
A12381-5Cambinol 5mg
A12381-50Cambinol 50mg
A12381-2Cambinol 2mg
A12381-1Cambinol 1mg
A12381-500Cambinol 500mg
A12381-25Cambinol 25mg
A12381-100Cambinol 100mg
A12381-10Cambinol 10mg
A12381-10mM-DCambinol 10mM * 1mL in DMSO

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