Anti-KRAS G12D mutant [D113], Mouse IgG1, kappa

Anti-KRAS G12D mutant [D113], Mouse IgG1, kappa

• Gene Name: [KRAS]
• NCBI Gene ID: 3845
• Reactivity: Human
• Storage Conditions: Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
• Specificity: This antibody binds the G12D mutant form of human KRAS protein. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein plays an important role in many signal transduction pathways and regulation of cell proliferation. Somatic KRAS mutations are highly observed in leukemias, colorectal cancer, pancreatic cancer and lung cancer. KRAS mutation is G12D which is estimated to be present in up to 37% pancreatic cancers and over 12% of colorectal cancers.
• Other Gene Names: [KRAS; KRAS; NS; NS3; CFC2; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS2; RASK2]
• Short Name: [KRAS G12D mutant]
• Other Product Names: [GTPase KRas; GTPase KRas; GTPase KRas; K-Ras 2; c-Ki-ras; oncogene KRAS2; K-ras p21 protein; c-Kirsten-ras protein; PR310 c-K-ras oncogene; transforming protein p21; cellular c-Ki-ras2 proto-oncogene; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; Kirsten rat sarcoma viral oncogene homolog; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-rasGTPase KRas, N-terminally processed]
• NCBI GI Number: 131875
• NCBI Accession Number: P01116.1
• Uniprot Accession Number: P01116