LY2874455

• Description:

  LY2874455 is a pan-FGFR inhibitor with IC50s of 2.8, 2.6, 6.4, 6 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  FGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/LY2874455.html

• Purity:

  99.14

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  ClC1=CN=CC (Cl) =C1[C@@H] (C) OC2=CC=C (NN=C3/C=C/C4=CN (CCO) N=C4) C3=C2

• Molecular Formula:

  C21H19Cl2N5O2

• Molecular Weight:

  444.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhao G, et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models. Molecular Cancer Therapeutics (2011), 10 (11), 2200-2210.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  1254473-64-7