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Timiperone

CAT: 0804-HY-127120Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-127120Size:1 mg
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Description
Timiperone has a strong affinity for cerebral dopamine D2 receptor. Timiperone has antipsychotic activity, and inhibits stereotyped behaviour. Timiperone can be used for research of schizophrenia[1][2][3].
CAS Number
[57648-21-2]
UNSPSC
12352005
Hazard Statement
H301
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/timiperone.html
Solubility
10 mM in DMSO
Smiles
S=C1NC2=CC=CC=C2N1C3CCN(CC3)CCCC(C4=CC=C(C=C4)F)=O
Molecular Formula
C22H24FN3OS
Molecular Weight
397.51
Precautions
H301
References & Citations
[1]Sudo K, et al. Disposition of timiperone, 4'-fluoro-4-[4- (2-thioxo-1-benzimidazolinyl) piperidino]butyrophenone, a neuroleptic, in the rat on repeated oral dosage. Xenobiotica. 1981 Oct;11 (10) :685-91.|[2]Kariya T, et al. A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique. J Int Med Res. 1983;11 (2) :66-77.|[3]Inada, K., et al. First-Generation Antipsychotics as a Bridge to Second-Generation Antipsychotics in the Japanese Pharmaceutical Industry: Mosapramine, Timiperone, Zotepine, and Nemonapride. NeuroPsychopharmacotherapy. Springer, Cham. (2021) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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