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CD00509

CAT: 0804-HY-W177546-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W177546-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT). CD00509 can be used for the study of cancers such as breast cancer[1][2][3].
CAS Number
27430-18-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; DNA/RNA Synthesis; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cd00509.html
Purity
98.0
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
S=C1NC(=O)C(C(N1)=O)=CC2=CC=CO2
Molecular Formula
C9H6N2O3S
Molecular Weight
222.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24 (21) :5017-5027.|[2]Dean RA, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19 (10) :1372-82.|[3]Dean RA, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19 (10) :1372-82. |[4]Segerer G, et al. An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation. Sci Rep. 2016 Oct 12;6:35160.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; PDE1

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CatalogName
T50033-01CD00509

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