1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)

CAT:

804-HY-N1743

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CAS Number: 376362-03-7
UNSPSC Description: 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].
Target Antigen: Phosphatase
Type: Natural Products
Related Pathways: Metabolic Enzyme/Protease
Applications: Metabolism-sugar/lipid metabolism
Field of Research: Metabolic Disease
Assay Protocol: https://www.medchemexpress.com/1-4-hydroxy-2-methoxyphenyl-3-4-hydroxy-3-prenylphenyl.html
Solubility: 10 mM in DMSO
Smiles: OC1=CC=C(CCCC2=CC=C(O)C=C2OC)C=C1C/C=C(C)\C
Molecular Weight: 326.43
References & Citations: [1]Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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TN2532-5mg	1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propa
TN2532-1g	1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propa
TN2532-50mg	1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propa
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