1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)

• UNSPSC Description:

  1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].

• Target Antigen:

  Phosphatase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/1-4-hydroxy-2-methoxyphenyl-3-4-hydroxy-3-prenylphenyl.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(CCCC2=CC=C(O)C=C2OC)C=C1C/C=C(C)\C

• Molecular Weight:

  326.43

• References & Citations:

  [1]Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  376362-03-7