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Chimaphilin

CAT: 0804-HY-N6611-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6611-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM) . Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].
CAS Number
482-70-2
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
IGF-1R
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chimaphilin.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C)=CC(C2=C1C=C(C)C=C2)=O
Molecular Formula
C12H10O2
Molecular Weight
186.21
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30.|[2]Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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