Ketanserin

• Description:

  Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM) .

• Product Name Alternative:

  R41468

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  5-HT Receptor; Autophagy; Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ketanserin.html

• Concentration:

  10mM

• Purity:

  99.89

• Solubility:

  DMF : 5 mg/mL (ultrasonic) |DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O

• Molecular Formula:

  C22H22FN3O3

• Molecular Weight:

  395.43

• Precautions:

  H302

• References & Citations:

  [1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155 (3) :365-73.|[2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.|[3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11 (9) :1471-1479.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  α-1 microglobulin

• CAS Number:

  [74050-98-9]