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Spiclomazine

CAT: 0804-HY-154313-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-154313-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spiclomazine (Clospirazine) is a potent mutant KRAS (G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
CAS Number
24527-27-3
Product Name Alternative
Clospirazine
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spiclomazine.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
Molecular Formula
C22H24ClN3OS2
Molecular Weight
446.03
References & Citations
[1]Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9 (6) :6938-6951.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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