Phospho-Lck (Tyr505) Rabbit APC Conjugate

• Description:

  Phospho-Lck (Tyr505) Rabbit APC Conjugate_x000D_ Catalog number: B2018901_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 ug_x000D_ Molecular Weight or Concentration: 58.00 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: 2-8„ƒ_x000D_ Keywords: Tyrosine-protein kinase Lck, Leukocyte C-terminal Src kinase, LSK, Protein YT16, T cell-specific protein-tyrosine kinase_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Woessner NM, Brandl SM, Hartmann S, Schamel WW, Hartl FA, Minguet S. Phospho-mimetic CD3ε variants prevent TCR and CAR signaling Front Immunol. 2024 May 8;15:1392933._x000D_ 2: Perbellini O, Cavallini C, Chignola R, Galasso M, Scupoli MT. Phospho-Specific Flow Cytometry Reveals Signaling Heterogeneity in T-Cell Acute Lymphoblastic Leukemia Cell Lines Cells. 2022 Jun 29;11(13):2072._x000D_ 3: Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT Nat Immunol. 2018 Jul;19(7):733-741._x000D_ 4: Rahmati A, Bigam S, Elahi S. Galectin-9 promotes natural killer cells activity via interaction with CD44 Front Immunol. 2023 Mar 16;14:1131379._x000D_ 5: Supper V, Hartl I, Boulègue C, Ohradanova-Repic A, Stockinger H. Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells J Immunol. 2017 Mar 15;198(6):2468-2478._x000D_ 6: Post CB, Gaul BS, Eisenmesser EZ, Schneider ML. NMR structure of phospho-tyrosine signaling complexes Med Res Rev. 1999 Jul;19(4):295-305._x000D_ 7: Kittipatarin C, Tschammer N, Khaled AR. The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7 Immunol Lett. 2010 Jul 8;131(2):170-81._x000D_ 8: Irles C, Arias-Martinez J, Guzmán-Bárcenas J, Ortega A. Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes Can J Physiol Pharmacol. 2010 Apr;88(4):487-96._x000D_ 9: Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B. Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions Cell Commun Signal. 2020 Nov 23;18(1):183._x000D_ 10: Sheng R, Jung DJ, Silkov A, Kim H, Singaram I, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Smrt S, Honig B, Baek K, Ryu S, Lorieau J, Kim YM, Cho W. Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain J Biol Chem. 2016 Aug 19;291(34):17639-50. _x000D_ _x000D_ Products Related to Phospho-Lck (Tyr505) Rabbit APC Conjugate can be found at Conjugates

• Short Description:

  Catalog Number: B2018901 (10 ug)_x000D_ Phospho-Lck (Tyr505) Rabbit APC Conjugate is an antibody that designed to detect the phosphorylated form of the Lck protein at the tyrosine residue 505 (Tyr505). Lck is a member of the Src family of tyrosine kinases and plays a crucial role in T-cell receptor signaling and other cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5