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BG47

CAT: 0804-HY-117583ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117583ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1].
CAS Number
1628784-54-2
UNSPSC
12352005
Target
HDAC; Histone Methyltransferase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bg47.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)/N=N/C2=CC=C(N(C)C)C=C2)NC3=C(O)C=CC(C4=CC=CS4)=C3
Molecular Formula
C25H22N4O2S
Molecular Weight
442.53
References & Citations
[1]Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12 (5) :317-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2

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