Products for Research Use Only
RegisterLogin

Praliciguat

CAT: 0804-HY-109039-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-109039-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase (sGC) activator. Praliciguat can increases cGMP via the nitric oxide (NO) -sGC pathway. Praliciguat can inhibit the expression of proinflammatory cytokines and inhibit apoptosis. Praliciguat can promote vasodilation. Praliciguat can be used for the researches of metabolic disease and cardiovascular disease, such as hypertension, diabetes and heart failure[1][2][3].
CAS Number
1628730-49-3
Product Name Alternative
IW-1973
UNSPSC
12352005
Target
Apoptosis; Guanylate Cyclase
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/praliciguat.html
Purity
99.35
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1=C(C=CC=C1)CN2C(C3=NOC=C3)=CC(C4=NC=C(F)C(NCC(C(F)(F)F)(O)C(F)(F)F)=N4)=N2
Molecular Formula
C21H14F8N6O2
Molecular Weight
534.36
References & Citations
[1]Daniel P Zimmer, et al. Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution.|[2]Liu G, et al. Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells. Am J Physiol Renal Physiol. 2020 Oct 1;319 (4) :F697-F711.|[3]Shea CM, et al. Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure. Am J Physiol Renal Physiol. 2020 Jan 1;318 (1) :F148-F159.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
MBS3843772-01Praliciguat
A19315-5Praliciguat 5mg
A19315-50Praliciguat 50mg
A19315-100Praliciguat 100mg
A19315-25Praliciguat 25mg
A19315-10Praliciguat 10mg
A19315-2Praliciguat 2mg
AR-P32262-01Praliciguat-d6
A19315-1Praliciguat 1mg
A19315-10mM-DPraliciguat 10mM * 1mL in DMSO

Popular Products