GAC0003A4

CAT: 0804-HY-160038-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-160038-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies[1].

CAS Number

929492-71-7

UNSPSC

12352005

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gac0003a4.html

Purity

98.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CC1)C2=C(C)C=CC=C2)C3=CC(OC)=CC(OC)=C3

Molecular Formula

C20H24N2O3

Molecular Weight

340.42

References & Citations

[1]Karaboga H, et al. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Nov 20;15 (11) :2916-2928.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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