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Psychosine

CAT: 0804-HY-136490-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136490-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].
CAS Number
2238-90-6
Product Name Alternative
Galactosylsphingosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psychosine.html
Purity
99.0
Smiles
O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC
Molecular Formula
C24H47NO7
Molecular Weight
461.63
Precautions
H302, H315, H319, H335
References & Citations
[1]M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121 (3) :271-278.|[2]Jacqueline A Hawkins-Salsbury, et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54 (12) :3303-11.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKC

Alternative Products

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T21260Psychosine
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900136Galactosylsphingosine (Psychosine)
MBS393565-01N-Acetyl-Psychosine
MBS393540-01N-Pentadecanoyl-Psychosine
900136KHGalactosylsphingosine (Psychosine) -KLH
900136BAGalactosylsphingosine (Psychosine) -BSA
MBS393536-01N-Stearoyl-D35-Psychosine
GWB-6D9011Anti- Psychosine receptor Antibody
T34181-01Psychosine-3'-sulfate ester

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