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Flibanserin

CAT: 0804-HY-A0095-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0095-01Size:5 mg
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Description
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].
CAS Number
[167933-07-5]
Product Name Alternative
BIMT-17; BIMT-17BS
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Flibanserin.html
Concentration
10mM
Purity
99.9
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3
Molecular Formula
C20H21F3N4O
Molecular Weight
390.40
Precautions
H301, H315, H319, H335
References & Citations
[1]Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021. |[2]Invernizzi RW, et al. A potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT (1A) receptors. Br J Pharmacol. 2003 Aug;139 (7) :1281-8. |[3]Gelez H, et al. Brain neuronal activation induced by flibanserin treatment in female rats. Psychopharmacology (Berl) . 2013 Dec;230 (4) :639-52. |[4]Podhorna J, et al. Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety. Br J Pharmacol. 2000 Jun;130 (4) :739-46. |[5]Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8 (1) :16-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

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