(E/Z)-SIS3 (free base)

(E/Z)-SIS3 (free base)

• CAS Number: 1009104-85-1
• UNSPSC Description: E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway[1].
• Target Antigen: TGF-beta/Smad
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/e-z-sis3-free-base.html
• Purity: 99.48
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1CC2=CC(OC)=C(C=C2CC1)OC)/C=C/C3=C(C4=CC=CC=C4)N(C)C5=NC=CC=C35
• Molecular Weight: 453.53
• References & Citations: [1]Shou J, et al., SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2018 Sep 5;503(2):757-762.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported