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Devazepide (Standard)

CAT: 0804-HY-106301R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106301R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Devazepide (Standard) is the analytical standard of Devazepide. This product is intended for research and analytical applications. Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1].
CAS Number
103420-77-5
Product Name Alternative
L-364,718 (Standard) ; MK-329 (Standard)
UNSPSC
12352005
Target
Cholecystokinin Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/devazepide-standard.html
Smiles
O=C(C1=CC2=C(C=CC=C2)N1)N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5N(C)C3=O
Molecular Formula
C25H20N4O2
Molecular Weight
408.45
References & Citations
[1]Chang RS, et al. Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proc Natl Acad Sci U S A. 1986 Jul;83 (13) :4923-6.|[2]Helen H Wang, et al. The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice. Eur J Clin Invest|[3]E Vasar, et al. Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse. Psychopharmacology (Berl) . 1991;105 (3) :393-9
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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