Walrycin B

• Description :

  Walrycin B, an analogue of toxoflavin, is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 of 0.26 μM. Walrycin B is a WalR response regulator inhibitor. Walrycin B has potent activity of inhibiting bacteria growth[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H320, H335

• Target :

  Antibiotic; Bacterial; SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/walrycin-b.html

• Purity :

  98.11

• Solubility :

  DMSO : 11.5 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=NC(C2=CC=C(C(F)(F)F)C=C2)=NN(C)C1=N3)N(C)C3=O

• Molecular Formula :

  C14H10F3N5O2

• Molecular Weight :

  337.26

• Precautions :

  H302, H315, H320, H335

• References & Citations :

  [1]Gotoh Y, et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo) . 2010 Mar;63 (3) :127-34.|[2]Wei Zhu, et al. Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening. bioRxiv. 2020 Aug 11:2020.07.17.207019.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [878419-78-4]