GARP&Latent TGF beta Complex, Mouse (HEK293, His)

GARP&Latent TGF beta Complex, Mouse (HEK293, His)

• UNSPSC Description: GARP/latent TGF-b1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. GARP&Latent TGF beta Complex Protein, Mouse (HEK293, His) is a biotinylated recombinant protein (GARP (I18-N628)&TGF-b1 (L30-S390)) produced by HEK293 cells with His tag[1][2].
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/garp-latent-tgf-beta-complex-protein-mouse-hek293-his.html
• Purity: 95.00
• Molecular Weight: 70-80 kDa
• References & Citations: [1]Soyoung A Oh,TGF-β: guardian of T cell function. J Immunol. 2013 Oct 15;191(8):3973-9.|[2]Angela X Zhou, et al. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013 May 15;190(10):5057-64.|[3]Justin P Edwards, et al. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. Eur J Immunol. 2016 Jun;46(6):1480-9.|[4]Dulce Maroni, et al. TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum. Cell Sci. 2011 Jul 15;124(Pt 14):2501-10.|[5]Justin Rustenhoven, et al. TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function. Justin Rustenhoven. 2016 Feb 11;13:37.|[6]Kai Zhang, et al. Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1. Transl Psychiatry. 2020 Jan 27;10(1):32.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years