Leptin

CAT: 0426-E21-067Size: 10 µgDry Ice: NoHazardous: No

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CAT#:0426-E21-067Size:10 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.

Description

Recombinant Human Leptin is produced by our E.coli expression system and the target gene encoding Val22-Cys167 is expressed.

Synonyms

Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS

Expression System

E. Coli

Endotoxin

Less than 0.1 ng/ µg (1 IEU/ µg) as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Form

Lyophilized

Shipping Conditions

The product is shipped at ambient temperature.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human

Shipping Temperature

Ambient

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PT_41403-01	Human Leptin (Leptin Human)
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Leptin

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