Araloside A

• Description:

  Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis[1][2][3][4].

• Product Name Alternative:

  Chikusetsusaponin IV

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Bcl-2 Family; Interleukin Related; Renin

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/araloside-a.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C([C@]1(CCC(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O[C@]7([H])O[C@@H](CO)[C@H](O)[C@H]7O)O)([H])O[C@@H]6C(O)=O)C5(C)C)C)[C@]3(C)CC1)O[C@@H]([C@@H]([C@@H](O)[C@@H]8O)O)O[C@@H]8CO

• Molecular Formula:

  C47H74O18

• Molecular Weight:

  927.08

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Takahashi S, et al. Inhibition of human renin activity by saponins. Biomed Res. 2010 Apr;31 (2) :155-9.|[2]Liu Y, et.al. The antitumor effects of Araloside A extracted from the root bark of Aralia elata on human kidney cancer cell lines. African Journal of Pharmacy and Pharmacology Vol. 5 (4), pp. 462-467, April 2011. |[3]Ding Y, et.al. Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chem Biol Interact. 2019 Jun 1;306:131-137.|[4]He H, et al. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. J Nat Med. 2019 Mar;73 (2) :339-352.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [7518-22-1]