SOX2 antibody

• Background:

  Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) .

• Synonyms:

  Transcription factor SOX-2|SOX2

• Gene ID:

  6657

• UniProt:

  P48431

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  SRY (sex determining region Y) -box 2

• Target:

  SOX2

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Neuroscience, Stem Cells, Metabolism, Epigenetics

• Purification:

  Protein A+G purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:50-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  34 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  1B5

• Tested Applications:

  ELISA, WB, IHC