CDH1 antibody

CAT: 0710-FNab10112Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab10112Size:100 µg
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Background
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Synonyms
Cadherin-1|CAM 120/80|Epithelial cadherin (E-cadherin) |Uvomorulin|E-Cad/CTF1|E-Cad/CTF2|E-Cad/CTF3|CDH1|CDHE|UVO
Gene ID
999
UniProt
P12830
Host
Mouse
Reactivity
Human
Immunogen
Cadherin 1, type 1, E-cadherin (epithelial)
Target
CDH1
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, IHC, WB, IF
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
Purification
Protein A+G purified
Dilution
WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
3G10
Tested Applications
ELISA, IHC, WB, IF

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