MGMT antibody

• Background:

  Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

• Synonyms:

  Methylated-DNA--protein-cysteine methyltransferase|6-O-methylguanine-DNA methyltransferase (MGMT) |O-6-methylguanine-DNA-alkyltransferase|MGMT

• Gene ID:

  4255

• UniProt:

  P16455

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  O-6-methylguanine-DNA methyltransferase

• Target:

  MGMT

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC

• Field of Research:

  Cancer, Immunology, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  IHC: 1:50 - 1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  22 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC