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PCDH15 antibody

CAT: 0710-FNab10098Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10098Size:100 µg
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Background
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F) . Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
Synonyms
Protocadherin-15|PCDH15|USH1F
Gene ID
65217
UniProt
Q96QU1
Host
Rabbit
Reactivity
Human, Rat
Immunogen
PCDH15
Target
PCDH15
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

UniProtKB · Q96QU1

Protocadherin-15

PCD15_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96QU1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PCDH15
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0A2R8Y6C0, A6NL19, C6ZEF5, C6ZEF6, C6ZEF7, Q5VY38, Q5VY39, Q6TRH8, Q8NDB9, Q96QT8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

Calcium

Biological process

Cell adhesionHearing

Cellular component

Cell membraneMembraneSecreted

Disease

DeafnessDisease variantNon-syndromic deafnessRetinitis pigmentosaUsher syndrome

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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