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CASP8 antibody

CAT: 0710-FNab10024Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10024Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816) . It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.
Synonyms
Caspase-8 (CASP-8) |Apoptotic cysteine protease|Apoptotic protease Mch-5|CAP4|FADD-homologous ICE/ced-3-like protease|FADD-like ICE (FLICE) |ICE-like apoptotic protease 5|MORT1-associated ced-3 homolog (MACH) |Caspase-8 subunit p18|Caspase-8 subunit p10|CASP8|MCH5
Gene ID
841
UniProt
Q14790
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Caspase 8, apoptosis-related cysteine peptidase
Target
CASP8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53-57 kDa, 32-45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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