AGER antibody

• Background :

  Mediates interactions of advanced glycosylation end products (AGE) . These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity) . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

• Synonyms :

  Advanced glycosylation end product-specific receptor|Receptor for advanced glycosylation end products|AGER|RAGE

• Gene ID :

  177

• UniProt :

  Q15109

• Host :

  Mouse

• Reactivity :

  Human, Rat

• Immunogen :

  Advanced glycosylation end product-specific receptor

• Target :

  AGER

• Clonality :

  Monoclonal

• Isotype :

  IgG1

• Applications :

  ELISA, WB

• Field of Research :

  Immunology, Signal Transduction, Developmental biology

• Purification :

  Protein A+G purified

• Dilution :

  WB: 1:1000-1:5000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  43 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  1B6

• Tested Applications :

  ELISA, WB