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HIF1A antibody

CAT: 0710-FNab09940Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09940Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256, .PMID: 7539918) .
Synonyms
Hypoxia-inducible factor 1-alpha (HIF-1-alpha, HIF1-alpha) |ARNT-interacting protein|Basic-helix-loop-helix-PAS protein MOP1|Class E basic helix-loop-helix protein 78 (bHLHe78) |Member of PAS protein 1|PAS domain-containing protein 8|HIF1A|BHLHE78|MOP1|PASD8
Gene ID
3091
UniProt
Q16665
Host
Mouse
Reactivity
Human
Immunogen
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Target
HIF1A
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IF, WB
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purified
Dilution
WB: 1:1000-1:10000; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
5H12
Tested Applications
ELISA, IF, WB

UniProtKB · Q16665

Hypoxia-inducible factor 1-alpha

HIF1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16665
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HIF1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HIF-1-alpha, HIF1-alpha
EC number
—
Processing
—
Secondary accessions
C0LZJ3, Q53XP6, Q96PT9, Q9UPB1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinHydroxylationIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionTranscriptionTranscription regulation

Domain

Repeat

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CSB-PA952643HIF1A Antibody

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