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PARP1 antibody

CAT: 0710-FNab09939Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09939Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly (ADP-ribosyl) ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis.
Synonyms
Poly [ADP-ribose] polymerase 1 (PARP-1) |ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1) |DNA ADP-ribosyltransferase PARP1|NAD (+) ADP-ribosyltransferase 1 (ADPRT 1) |Poly[ADP-ribose] synthase 1|Protein poly-ADP-ribosyltransferase PARP1|Poly [ADP-ribose] polymerase 1, processed C-terminus Alternative names: Poly [ADP-ribose] polymerase 1, 89-kDa form|Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) Alternative names: Poly [ADP-ribose] polymerase 1, 24-kDa form|Poly [ADP-ribose] polymerase 1, 28-kDa form|PARP1|ADPRT|PPOL
Gene ID
142
UniProt
P09874
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Poly (ADP-ribose) polymerase 1
Target
PARP1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Protein A+G purified
Dilution
WB: 1:5000 - 1:30000; IHC: 1:100 - 1:1000; IF: 1:50 - 1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
115 kDa, 89 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
4A9
Tested Applications
ELISA, WB, IHC, IF

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