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SOCS1 antibody

CAT: 0710-FNab09926Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09926Size:100 µg
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Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Synonyms
Suppressor of cytokine signaling 1 (SOCS-1) |JAK-binding protein (JAB) |STAT-induced STAT inhibitor 1 (SSI-1) |Tec-interacting protein 3 (TIP-3) |SOCS1|SSI1|TIP3
Gene ID
8651
UniProt
O15524
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Suppressor of cytokine signaling 1
Target
SOCS1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50-1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
Peptide

UniProtKB · O15524

Suppressor of cytokine signaling 1

SOCS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15524
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOCS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SOCS-1
EC number
—
Processing
—
Secondary accessions
O15097, Q9NSA7
Protein keywords

Cellular component

Cytoplasmic vesicleNucleus

Disease

Disease variant

Biological process

Growth regulationUbl conjugation pathway

Technical term

Proteomics identificationReference proteome

Domain

SH2 domain

Molecular function

Signal transduction inhibitor

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