SNCA antibody

• Background:

  Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

• Synonyms:

  Alpha-synuclein|Non-A beta component of AD amyloid|Non-A4 component of amyloid precursor (NACP) |SNCA|NACP|PARK1

• Gene ID:

  6622

• UniProt:

  P37840

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synuclein, alpha (non A4 component of amyloid precursor)

• Target:

  SNCA

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, IHC, WB

• Field of Research:

  Neuroscience

• Purification:

  Protein A+G purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  18 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  5C6

• Tested Applications:

  ELISA, IHC, WB