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GOT1 antibody

CAT: 0710-FNab09876Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09876Size:100 µg
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Background
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H (2) S via the action of 3-mercaptopyruvate sulfurtransferase (3MST) . Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Synonyms
Aspartate aminotransferase, cytoplasmic (cAspAT) |Cysteine aminotransferase, cytoplasmic|Cysteine transaminase, cytoplasmic (cCAT) |Glutamate oxaloacetate transaminase 1|Transaminase A|GOT1
Gene ID
2805
UniProt
P17174
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
Target
GOT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43-46 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB

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