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TNF alpha antibody

CAT: 0710-FNab09822Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09822Size:100 µg
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Background
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Synonyms
Tumor necrosis factor|Cachectin|TNF-alpha|Tumor necrosis factor ligand superfamily member 2 (TNF-a) |Tumor necrosis factor, membrane form Alternative names: N-terminal fragment (NTF) |Intracellular domain 1 (ICD1) |Intracellular domain 2 (ICD2) |C-domain 1|C-domain 2|Tumor necrosis factor, soluble form|TNF|TNFA|TNFSF2
Gene ID
7124
UniProt
P01375
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tumor necrosis factor (TNF superfamily, member 2)
Target
TNF alpha
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:1000 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
21 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
82-233aa

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