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ZW10 antibody

CAT: 0710-FNab09760Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09760Size:100 µg
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Background
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131) . Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER) ; the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241) .
Synonyms
Centromere/kinetochore protein zw10 homolog|ZW10
Gene ID
9183
UniProt
O43264
Host
Rabbit
Reactivity
Human
Immunogen
ZW10, kinetochore associated, homolog (Drosophila)
Target
ZW10
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cell Division and Proliferation, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · O43264

Centromere/kinetochore protein zw10 homolog

ZW10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43264
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZW10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1A528
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionER-Golgi transportMitosisProtein transportTransport

Cellular component

CentromereChromosomeCytoplasmCytoskeletonEndoplasmic reticulumKinetochoreLipid dropletMembrane

Domain

Coiled coil

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