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ZEB1 antibody

CAT: 0710-FNab09620Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09620Size:100 µg
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Background
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3') . Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
Synonyms
Zinc finger E-box-binding homeobox 1|NIL-2-A zinc finger protein|Negative regulator of IL2|Transcription factor 8 (TCF-8) |ZEB1|AREB6|TCF8
Gene ID
6935
UniProt
P37275
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Zinc finger E-box binding homeobox 1
Target
ZEB1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP,IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
210 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC
Immunogen Sequence
391-739aa

UniProtKB · P37275

Zinc finger E-box-binding homeobox 1

ZEB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P37275
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZEB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DJV0, B4DUW9, E9PCM7, F5H4I8, Q12924, Q13800, Q2KJ05, Q5T968, Q5VZ84, Q8NB68
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Disease

Corneal dystrophyDisease variant

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Domain

HomeoboxRepeatZinc-finger

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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Alternative Products

CatalogName
CSB-PA026424LA01HU-01ZEB1 Antibody

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