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ZBTB38 antibody

CAT: 0710-FNab09593Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09593Size:100 µg
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Background
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3') . Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688) . Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6-and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359) . Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity) .
Synonyms
Zinc finger and BTB domain-containing protein 38|ZBTB38
Gene ID
253461
UniProt
Q8NAP3
Host
Rabbit
Reactivity
Human
Immunogen
Zinc finger and BTB domain containing 38
Target
ZBTB38
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
134 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q8NAP3

Zinc finger and BTB domain-containing protein 38

ZBT38_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NAP3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZBTB38
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DNF6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingRepressor

Cellular component

ChromosomeNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

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