VPS41 antibody

CAT: 0710-FNab09442Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09442Size:100 µg
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Background
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085) . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847) . Required for fusion of autophagosomes with lysosomes (PubMed:25783203) . May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847) . Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049) . Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity) . May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660) .
Synonyms
Vacuolar protein sorting-associated protein 41 homolog|S53|VPS41
Gene ID
27072
UniProt
P49754
Host
Rabbit
Reactivity
Human
Immunogen
Vacuolar protein sorting 41 homolog
Target
VPS41
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa, 93 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

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