USP44 antibody

• Background:

  Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.

• Synonyms:

  Ubiquitin carboxyl-terminal hydrolase 44|Deubiquitinating enzyme 44|Ubiquitin thioesterase 44|Ubiquitin-specific-processing protease 44|USP44

• Gene ID:

  84101

• UniProt:

  Q9H0E7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  ubiquitin specific peptidase 44

• Target:

  USP44

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  81 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4