PLAUR antibody

• Background:

  Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

• Synonyms:

  Urokinase plasminogen activator surface receptor (U-PAR, uPAR) |Monocyte activation antigen Mo3|PLAUR|MO3|UPAR

• UniProt:

  Q03405

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Plasminogen activator, urokinase receptor

• Target:

  PLAUR

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP

• Field of Research:

  Immunology, Cardiovascular, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000; IP: 1:200-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  37-70 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP

• Immunogen Sequence:

  23-305aa