UNC13A antibody

• Background :

  UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP) . It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion. The antibody is specific to UNC13A.

• Synonyms :

  Protein unc-13 homolog A|Munc13-1|UNC13A|KIAA1032

• Gene ID :

  23025

• UniProt :

  Q9UPW8

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Unc-13 homolog A (C. elegans)

• Target :

  UNC13A

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:5000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  193 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB