TXNIP antibody

TXNIP antibody

• Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1).
• Synonyms: Thioredoxin-interacting protein|Thioredoxin-binding protein 2|Vitamin D3 up-regulated protein 1|TXNIP|VDUP1
• CAS Number: 9007-83-4
• Gene ID: 10628
• UniProt: Q9H3M7
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: thioredoxin interacting protein
• Target: TXNIP
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, IHC, WB, IF
• Field of Research: Metabolism
• Purification: Immunogen affinity purified
• Dilution: WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 50 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)