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TSHR antibody

CAT: 0710-FNab09045Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09045Size:100 µg
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Background
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. The gene of TSHR maps to chromosome 14q31.1, and encodes a 764-amino acid protein with a predicted unmodified molecular weight of 86.8 kDa. The apparent molecular weight of glycosylated form is 95-120 kDa. Studies reveal that TSHR is composed of two subunits, A and B, which are produced by cleavage of single-chain TSHR on the cell surface and subsequently connected by disulfide bonds. This rabbit polyclonal antibody can detect glycosylated subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition. (PMID: 20578897, 17158770, 12593718)
Synonyms
Thyrotropin receptor|Thyroid-stimulating hormone receptor (TSH-R) |TSHR|LGR3
Gene ID
7253
UniProt
P16473
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Thyroid stimulating hormone receptor
Target
TSHR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20- 1:50
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62-100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
P16473-2,21-253AA

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