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TRIM63 antibody

CAT: 0710-FNab08992Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08992Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Synonyms
E3 ubiquitin-protein ligase TRIM63|Iris RING finger protein|Muscle-specific RING finger protein 1 (MuRF-1, MuRF1) |RING finger protein 28|RING-type E3 ubiquitin transferase TRIM63|Striated muscle RING zinc finger protein|Tripartite motif-containing protein 63|TRIM63|IRF|MURF1|RNF28|SMRZ
Gene ID
84676
UniProt
Q969Q1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tripartite motif-containing 63
Target
TRIM63
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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