Products for Research Use Only
RegisterLogin

TPX2 antibody

CAT: 0710-FNab08910Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0710-FNab08910Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764) . Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764) . TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940) . At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940) .
Synonyms
Targeting protein for Xklp2|Differentially expressed in cancerous and non-cancerous lung cells 2 (DIL-2) |Hepatocellular carcinoma-associated antigen 519|Hepatocellular carcinoma-associated antigen 90|Protein fls353|Restricted expression proliferation-associated protein 100 (p100) |TPX2|C20orf1|C20orf2|DIL2|HCA519
Gene ID
22974
UniProt
Q9ULW0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TPX2, microtubule-associated, homolog (Xenopus laevis)
Target
TPX2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP
Immunogen Sequence
1-256aa

Related Products

CatalogName
P2795-01Recombinant Human TPX2
EH5265Human TPX2 (Targeting protein for Xklp2) ELISA Kit
FNab11062CA125 antibody (capture antibody)
FNab11060AFP antibody (capture antibody)
FNab11045-01CEA antibody (detection antibody)
FNab11061CA125 antibody (detection antibody)
FNab11059AFP antibody (detection antibody)
FNab11046-01CEA antibody (capture antibody)
FNab09471WAS antibody
FNab11063CA19-9 antibody (detection antibody)

Alternative Products

CatalogName
10R-1417TPX2 antibody

Popular Products