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TNIP2 antibody

CAT: 0710-FNab08832Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08832Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus-and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Synonyms
TNFAIP3-interacting protein 2|A20-binding inhibitor of NF-kappa-B activation 2 (ABIN-2) |Fetal liver LKB1-interacting protein|TNIP2|ABIN2|FLIP1
Gene ID
79155
UniProt
Q8NFZ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TNFAIP3 interacting protein 2
Target
TNIP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC

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