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TMEM59 antibody

CAT: 0710-FNab08787Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08787Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) . Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Synonyms
Transmembrane protein 59|Liver membrane-bound protein|TMEM59|C1orf8
Gene ID
9528
UniProt
Q9BXS4
Host
Rabbit
Reactivity
Human
Immunogen
Transmembrane protein 59
Target
TMEM59
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
41 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF

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