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TIA1 antibody

CAT: 0710-FNab08685Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08685Size:100 µg
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Background
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Synonyms
Cytotoxic granule associated RNA binding protein TIA1|Nucleolysin TIA-1 isoform p40|RNA-binding protein TIA-1|T-cell-restricted intracellular antigen-1 (TIA-1) |p40-TIA-1|TIA1
Gene ID
7072
UniProt
P31483
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TIA1 cytotoxic granule-associated RNA binding protein
Target
TIA1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · P31483

Cytotoxic granule associated RNA binding protein TIA1

TIA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31483
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TIA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q53SS9, Q96B58
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

ApoptosismRNA processingmRNA splicing

Cellular component

CytoplasmNucleus

Domain

Repeat

Molecular function

RNA-binding

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