THOC7 antibody

• Background :

  Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

• Synonyms :

  THO complex subunit 7 homolog|Functional spliceosome-associated protein 24 (fSAP24) |Ngg1-interacting factor 3-like protein 1-binding protein 1 (NIF3L1-binding protein 1) |hTREX30|THOC7|NIF3L1BP1

• Gene ID :

  80145

• UniProt :

  Q6I9Y2

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  THO complex 7 homolog (Drosophila)

• Target :

  THOC7

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  24 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC